Stroke

  • Sudden brain damage
  • Lack of blood flow to the brain caused by a clot or rupture of a blood vessel
  • —Affects ~ 800,000 people per year
  • —Leading cause of disability, cognitive impairment, and death in U.S.
  • U.S. cost for 2012 = $71.5 billion
  • Projected to increase to $240.67 billion by 2030, an increase of 129%

Stroke Treatments

  • —Thrombolytics
  • Administration must be before 3-4 hours
  • —Aim is to reduce progression of damage
  • Restore neuronal function in “stunned” penumbra
  • —No treatments beneficial after stroke occurred