What is AmnioStem?

  • —Amniotic fluid derived stem cell
  • —Issued US patent, licensed from UCSD
  • —Covering composition of matter and practical isolation procedures for amniotic fluid stem cells

AmnioStem Patent Covers Means to Isolate, Grow and Use Amniotic Fluid Derived Stem Cells in a Scalable and Commercializable Manner”

Why is Amniotic Fluid Special?

  • Clear, yellowish liquid, surrounds fetus during pregnancy
  • Continuously inhaled, exhaled by fetus
  • —98% water, proteins, peptides, carbohydrates, lipids and hormones
  • Protects the developing fetus, promotes growth

Amniotic Fluid Stem Cells

  • —2001: Atala group postulates existence of c-kit positive stem cells, no means of practical expansion
  • 2003: Prusa et al described stem cell markers in amniotic fluid, no means of expansion
  • 2003: Martin Haas at UCSD (our inventor) Practical protocol for isolation, expansion and growth of amniotic fluid stem cells
  • —2007: First publication on practical use of amniotic stem cells (DeCoppi et al)

“Since 2007 there have been over 600 peer-reviewed publications on the benefits of amniotic fluid stem cells”

AmnioStem is Practical Stem Cell Therapy

  • ——Practical protocol for generating therapeutic quality stem cells starting from small (1-5 ml) amniocentesis sample
  • —Do not mutate and maintain phenotype
  • Large scale expansion of stem cells feasible, with 1 donor generating >20,000 doses
  • —AmnioStem cells do not require matching with recipient (one size fits all)

Location on The Stem Cell Continuum

Generation of Therapeutic Amniotic Fluid Derived Stem Cells

Advantages

Embryonic
Stem Cells
Amniotic Fluid Stem Cells Adult
Stem Cells
Developmental potential Pluripotent Pluripotent or multipotent Multipotent
Renewal capacity Very high expansion in cell culture High expansion Limited
Potential for tumor formation Yes No No
Ethical considerations Serious ethical issues raised using embryos No issues; obtained during routine procedures No